is the leading gynaecopathologist within Amsterdam University Medical Center (Amsterdam UMC), She is chair of the group of pathologists who are involved in the diagnostic, educational and research field of gynaecopathology at Amsterdam UMC. She is chair of the Dutch working group for gynaecopathology and participates in several multidisciplinary working groups on oncologic guidelines for gynaecopathology.
Since 1999, her main research field concerns studies on HPV related genital (pre)cancers. This research line embodies a translational pipeline from cancer biology to biomarker discovery towards clinical validation (www.hpvstudies.nl). The strength of this research line relates to the fact that in vitro studies using unique model systems run in parallel to molecular discovery and validation studies on well-characterized patient materials. She has completed her PhD trajectory on “HPV infection in sexual partners” with summa cum laude. This trajectory was also embedded in this research group and included research into the male role in HPV transmission and insight into the clinical presentation of HPV infections in men. This niche has resulted in involvement in several (inter)national research projects related to this topic.
Current projects focus on identification, detection and validation of biomarkers for risk stratification in precursor lesions of vulvar cancer (VENUS study) and triage in HPV positive cytology samples of women who participate in the cervical screening program in the Netherlands and Europe (IMPROVE study, VALID-SCREEN study), She is project leader of the multicentre SOLUTION study in which cytology samples including cervical scrapes, vaginal swabs and urine are collected to search for biomarkers to detect gynaecologic cancer and cervical precancerous lesions. The research team is highly interdisciplinary and consists of clinicians, molecular biologists and biostatisticians.
She recently completed her membership in the Health Council resulting in a revised HPV vaccination advice to the Dutch minister of Health.