Herjan Coelingh Bennink (HCB), MD, PhD
Herjan Coelingh Bennink (HCB), MD, PhD, trained in Internal Medicine and Gynaecology in the Netherlands and certified in 1976 as specialist in ObGyn. In 1974 he was Research Fellow at the Centre of Reproductive Biology, University of Michigan, Ann Arbor, USA (Prof Jan Behrman). Since 1976 he was director of the Department of Reproductive Endocrinology at the University Hospital in Utrecht. In 1980 he completed his PhD thesis on Gestational Diabetes. From 1997-2005 HCB was visiting professor Reproductive Medicine (RM) at the Free University in Brussels, Belgium (profs Devroey and van Steirteghem).
From 1987-2000 HCB was Executive VP of the Women’s Health R&D programme at Organon in The Netherlands, where he was responsible for the development of RM drugs such as recFSH (Puregon) and the GnRH antagonist Antagon, both for IVF; the contraceptive vaginal ring (Nuvaring), a progestogen implant for contraception (Implanon), a progestogen-only desogestrel oral contraceptive (Cerazette) and the steroid tibolone (Livial) for menopausal hormone therapy (MHT).
HCB founded Pantarhei Bioscience in December 2000, where he discovered (i) the natural fetal estrogen Estetrol (E4) as a drug for human use, licensed out to Mithra Pharmaceuticals in Belgium in 2015 for oral contraception and MHT, (ii) a new combined contraceptive pill containing DHEA to prevent symptoms caused by the loss of testosterone due to COCs (the Androgen Restored Contraception (ARC) pill), and (iii) an immunotherapy for the treatment of Zona Pellucida 3 Cancer (ZP3C) antigen expressing ovarian, prostate, breast, colon and non-small cell lung cancer (NSCLC). In 2014 Pantarhei Oncology was founded as a subsidiary of Pantarhei Bioscience to develop new cancer drugs in the field of Reproductive Endocrine Oncology (REO), with a focus on high dose E4 treatment of advanced breast cancer (BCa) and advanced prostate cancer (PCa). For both E4 cancer applications successful phase 2 proof-of-concept studies have been completed and published and next phase 2 and 3 studies are in preparation.
March 2024
