Kevin D Sinclair, PhD, DSc
Professor of Developmental Biology, Head of Division of Animal Sciences, University of Nottingham.
Research interests lie in metabolic programming during early development, where epigenetic outcomes are determined in embryonic cells and tissues, and long-term developmental consequences assessed in offspring. First to discover that developmental anomalies following embryo culture were due to errors in genomic imprinting. Also, first to demonstrate that reductions in folate and vitamin B12 in maternal diets lead to epigenetic modifications to DNA methylation associated with hypertensive and insulin resistant offspring. Subsequently demonstrated that paternal malnutrition epigenetically modifies DNA methylation and adversely affects cardio-metabolic health in offspring. Published the first detailed reports of cardio-metabolic and musculo-skeletal health in aged cloned offspring, and provided details of concordant DNA methylation in embryonic and somatic-cell lineages. Ongoing work is assessing the nature and extent of aneuploidy and epigenetic dysregulation following mammalian embryo culture.
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